Scientists have found the ‘missing link’ to a common, ancient form of calcium ion, says paper
A new paper in the Proceedings of the National Academy of Sciences, which looked at the distribution of calcium ions in the human body and found that they are distributed in a more regular, hierarchical pattern than previously thought, says the paper’s lead author, Anil Madhav, a researcher at the Tata Institute of Fundamental Research.
This suggests that the way we naturally arrange calcium in our bodies is important to the formation of our own calcium ions.
The researchers say their findings could have important implications for understanding the origins of many diseases.
They found that calcium ions form at a relatively high rate in the brain, where they are thought to mediate the process of regulating calcium levels.
The team hypothesised that this could be due to the fact that calcium is a key building block of the nervous system and that the brain is where the most complex processes of the brain take place.
“There are other pathways that could be involved,” Madhava said.
Madhavan said the researchers had previously identified a calcium ion that was similar to calcium in the cells of the blood. “
So, if you put calcium ions into the brain and let them do their thing, then you will get calcium ion density in the blood.”
Madhavan said the researchers had previously identified a calcium ion that was similar to calcium in the cells of the blood.
“But that was only found in a few patients, and it was very limited,” he said.
This study is important because the researchers found that in the brains of healthy volunteers, calcium ions are distributed differently, according to the structure of the human blood cells.
“We found that the different concentrations of calcium in different regions of the CSFs are related to the calcium ions’ distribution in the cell membranes,” Madav said.
The finding has implications for the way calcium ions and other substances that can be found in the body are regulated.
“Our hypothesis is that in normal cells, calcium ion formation occurs in an organized way, where the ion can diffuse from the cell membrane to the rest of the cell, which then regulates the cell’s internal structure,” Madhan said.
For instance, in cells that do not normally contain calcium ions, the ion will diffuse to other tissues, such as muscle cells.
If the blood has a high concentration of calcium, then the cell will accumulate calcium ions that are similar to those in the nervous systems, and if the cells have a low concentration, then they will accumulate less calcium ions than the cells without calcium ions present.
“When calcium ions diffuse to tissues, it can influence their structure and function,” Madhapav said, adding that in humans, it has been well established that calcium concentration is linked to the ability of a certain type of brain cell to process calcium ions (called calcium channels).
He said that the findings also support the idea that the calcium ion in the circulatory system can influence the amount of calcium that is found in blood and in other bodily fluids.
Madhapev said that a study published in the journal Molecular Brain Research suggested that this mechanism could be responsible for a large proportion of the variation in blood calcium levels, but he was unsure whether this would hold true for other forms of calcium.
“The calcium ion is very complex,” Madhaav said “The ion itself is highly organized and there are many different kinds of calcium channels.”
“What’s more, in our brain cells, we have a complex system of calcium receptors that all work in concert,” Madhatav said adding that the receptor network is a complex process and there is “huge variation in receptor expression and the receptor proteins that we can detect.”
The researchers plan to explore the function of calcium channel proteins in other brain regions, and also explore the possibility of studying the functions of calcium and calcium ions on the body in different ways.
They also plan to study how calcium ion and other chemicals affect the body’s internal processes.
“Calcium ions are involved in many processes that have been linked to inflammation,” Madharav said